Drug Interactions
Febuxostat is contraindicated with concomitant use of theophylline and chemotherapeutic agents, namely azathioprine and 6-mercaptopurine, because it could increase blood plasma concentrations of these drugs, and therefore their toxicity. However, according to 2012 data, theophylline can be administered in usual doses in combination with febuxostat, as the latter does not affect the plasma pharmacokinetics of theophylline. While it does affect the pharmacokinetics of 1-methylxanthine and 1-methyluric acid, these do not have any pharmacological effects.
Read more about this topic: Febuxostat
Famous quotes containing the words drug and/or interactions:
“Most people aren’t appreciated enough, and the bravest things we do in our lives are usually known only to ourselves. No one throws ticker tape on the man who chose to be faithful to his wife, on the lawyer who didn’t take the drug money, or the daughter who held her tongue again and again. All this anonymous heroism.”
—Peggy Noonan (b. 1950)
“In our interactions with people, a benevolent hypocrisy is frequently required—acting as though we do not see through the motives of their actions.”
—Friedrich Nietzsche (1844–1900)