Drug Interactions
Febuxostat is contraindicated with concomitant use of theophylline and chemotherapeutic agents, namely azathioprine and 6-mercaptopurine, because it could increase blood plasma concentrations of these drugs, and therefore their toxicity. However, according to 2012 data, theophylline can be administered in usual doses in combination with febuxostat, as the latter does not affect the plasma pharmacokinetics of theophylline. While it does affect the pharmacokinetics of 1-methylxanthine and 1-methyluric acid, these do not have any pharmacological effects.
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