Fatty Acid Synthase
Gene Ontology | |
---|---|
Molecular function | • nucleotide binding • fatty acid synthase activity • • • 3-oxoacyl- • 3-oxoacyl- • 3-hydroxypalmitoyl- • enoyl- • oleoyl- • protein binding • zinc ion binding • myristoyl- • palmitoyl- • 3-hydroxyoctanoyl- |
Cellular component | • cytoplasm • mitochondrion • Golgi apparatus • cytosol • plasma membrane • melanosome • glycogen granule |
Biological process | • energy reserve metabolic process • fatty acid metabolic process • fatty acid biosynthetic process • vitamin metabolic process • water-soluble vitamin metabolic process • pantothenate metabolic process • triglyceride biosynthetic process • positive regulation of cellular metabolic process • long-chain fatty-acyl-CoA biosynthetic process • cellular lipid metabolic process • small molecule metabolic process |
Sources: Amigo / QuickGO |
80.04 – 80.06 Mb
120.81 – 120.82 Mb
Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene.
Fatty acid synthase is a multi-enzyme protein that catalyzes fatty acid synthesis. It is not a single enzyme but a whole enzymatic system composed of two identical 272 kDa multifunctional polypeptides, in which substrates are handed from one functional domain to the next.
Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids.
Read more about Fatty Acid Synthase: Metabolic Function, Classes, Structure, Regulation, Clinical Significance