Farnesoid X Receptor

Farnesoid X Receptor

Identifiers Symbols NR1H4; BAR; FXR; HRR-1; HRR1; RIP14 External IDs OMIM: 603826 MGI: 1352464 HomoloGene: 3760 IUPHAR: NR1H4 ChEMBL: 2047 GeneCards: NR1H4 Gene

Gene Ontology
Molecular function	• RNA polymerase II distal enhancer sequence-specific DNA binding • RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription • double-stranded DNA binding • sequence-specific DNA binding transcription factor activity • RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity • steroid hormone receptor activity • transcription coactivator activity • transcription corepressor activity • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity • thyroid hormone receptor activity • protein binding • zinc ion binding • ligand-dependent nuclear receptor binding • bile acid binding • peptide binding • sequence-specific DNA binding • metal ion binding • retinoid X receptor binding
Cellular component	• nucleoplasm • nuclear euchromatin
Biological process	• negative regulation of transcription from RNA polymerase II promoter • nitrogen catabolite activation of transcription from RNA polymerase II promoter • regulation of carbohydrate metabolic process • transcription initiation from RNA polymerase II promoter • signal transduction • bile acid metabolic process • response to glucose stimulus • gene expression • intracellular receptor mediated signaling pathway • response to lipopolysaccharide • regulation of urea metabolic process • positive regulation of transcription from RNA polymerase II promoter • digestive tract development • regulation of bile acid biosynthetic process • cellular response to acid • cellular response to organic nitrogen • regulation of cholesterol metabolic process • positive regulation of glutamate metabolic process • positive regulation of ammonia assimilation cycle
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9971 20186 Ensembl ENSG00000012504 ENSMUSG00000047638 UniProt Q96RI1 Q60641 RefSeq (mRNA) NM_001206977.1 NM_001163504.1 RefSeq (protein) NP_001193906.1 NP_001156976.1 Location (UCSC) Chr 12:
100.87 – 100.96 Mb Chr 10:
89.45 – 89.53 Mb PubMed search

The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans.