Related Exotic Structures
Casson handles are homeomorphic to D2×R2 by Freedman's theorem (where D2 is the closed unit disc) but it follows from Donaldson's theorem that they are not all diffeomorphic to D2×R2. In other words, some Casson handles are exotic D2×R2s.
It is not known (as of 2009) whether or not there are any exotic 4-spheres; such an exotic 4-sphere would be a counterexample to the smooth generalized Poincaré conjecture in dimension 4. Some plausible candidates are given by Gluck twists.
Read more about this topic: Exotic R4
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