Quality of Clinical Trials
Evidence-based medicine attempts to objectively evaluate the quality of clinical research by critically assessing techniques reported by researchers in their publications.
- Trial design considerations. High-quality studies have clearly defined eligibility criteria and have minimal missing data.
- Generalizability considerations. Studies may only be applicable to narrowly defined patient populations and may not be generalizable to other clinical contexts.
- Follow-up. Sufficient time for defined outcomes to occur can influence the study outcomes and the statistical power of a study to detect differences between a treatment and control arm.
- Power. A mathematical calculation can determine if the number of patients is sufficient to detect a difference between treatment arms. A negative study may reflect a lack of benefit, or simply a lack of sufficient quantities of patients to detect a difference.
Read more about this topic: Evidence-based
Famous quotes containing the words quality of, quality and/or trials:
“It is not stressful circumstances, as such, that do harm to children. Rather, it is the quality of their interpersonal relationships and their transactions with the wider social and material environment that lead to behavioral, emotional, and physical health problems. If stress matters, it is in terms of how it influences the relationships that are important to the child.”
—Felton Earls (20th century)
“So much has already been said about Shakespeare that there doesn’t seem to be anything more to say; yet it is the quality of the spirit that it forever stimulates the spirit.”
—Johann Wolfgang Von Goethe (1749–1832)
“Old age is not a disease—it is strength and survivorship, triumph over all kinds of vicissitudes and disappointments, trials and illnesses.”
—Maggie Kuhn (b. 1905)