Quality of Clinical Trials
Evidence-based medicine attempts to objectively evaluate the quality of clinical research by critically assessing techniques reported by researchers in their publications.
- Trial design considerations. High-quality studies have clearly defined eligibility criteria and have minimal missing data.
- Generalizability considerations. Studies may only be applicable to narrowly defined patient populations and may not be generalizable to other clinical contexts.
- Follow-up. Sufficient time for defined outcomes to occur can influence the study outcomes and the statistical power of a study to detect differences between a treatment and control arm.
- Power. A mathematical calculation can determine if the number of patients is sufficient to detect a difference between treatment arms. A negative study may reflect a lack of benefit, or simply a lack of sufficient quantities of patients to detect a difference.
Read more about this topic: Evidence-based
Famous quotes containing the words quality of, quality and/or trials:
“A person must have a good memory to keep the promises he has made. A person must have a strong imagination to be able to have pity. So closely is morality tied to the quality of the intellect.”
—Friedrich Nietzsche (1844–1900)
“The point is, that the function of the novel seems to be changing; it has become an outpost of journalism; we read novels for information about areas of life we don’t know—Nigeria, South Africa, the American army, a coal-mining village, coteries in Chelsea, etc. We read to find out what is going on. One novel in five hundred or a thousand has the quality a novel should have to make it a novel—the quality of philosophy.”
—Doris Lessing (b. 1919)
“All trials are trials for one’s life, just as all sentences are sentences of death.”
—Oscar Wilde (1854–1900)