Safety
Ethylenediamine, like most amines, is a skin irritant. It was used in commercially available skin products including Mycolog cream. Unless tightly contained, ethylenediamine will release toxic and irritating vapors into its surroundings, especially on heating. The vapors react with moisture in humid air to form a characteristic white mist, which is extremely irritating to skin, eyes, lungs and mucus membranes. Exposure to a relatively small amount of vapor or mist by inhalation can seriously damage health, and may even result in death. Ethylenediamine has a half-life of about 30 minutes and a small volume of distribution of 0.133 liters/kg. After oral administration its bioavailability is about 0.34, due to a substantial first-pass effect. Less than 20% is eliminated by urinal excretion.
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