Esopus may refer to:
- In New York
- Esopus, New York, a town in Ulster County
- Esopus Creek, a tributary of the Hudson River
- Esopus Meadows Lighthouse, a lighthouse on the Hudson River near Esopus, New York
- Esopus Wars, two localized conflicts between Dutch settlers and the Esopus tribe of Lenape Indians during the latter half of the 17th century
- Esopus (magazine), a nonprofit arts publication based in New York
- Esopus tribe, a tribe of Lenape Indians
- Esopus Spitzenburg, a type of apple
- Other
- Esopus (genus), a genus of crabs in the family Epialtidae
- A medieval spelling of Aesop