Esopus may refer to:

In New York
  • Esopus, New York, a town in Ulster County
  • Esopus Creek, a tributary of the Hudson River
  • Esopus Meadows Lighthouse, a lighthouse on the Hudson River near Esopus, New York
  • Esopus Wars, two localized conflicts between Dutch settlers and the Esopus tribe of Lenape Indians during the latter half of the 17th century
  • Esopus (magazine), a nonprofit arts publication based in New York
  • Esopus tribe, a tribe of Lenape Indians
  • Esopus Spitzenburg, a type of apple
  • Esopus (genus), a genus of crabs in the family Epialtidae
  • A medieval spelling of Aesop