TMPRSS2 Gene Fusion
ERG can fuse with TMPRSS2 protein to form an oncogenic fusion gene that is commonly found in human prostate cancer, especially in hormone-refractory prostate cancer. This suggests that ERG overexpression may contribute to development of androgen-independence in prostate cancer through disruption of androgen receptor signaling.
Read more about this topic: ERG (gene)
Famous quotes containing the word fusion:
“No ... the real American has not yet arrived. He is only in the Crucible, I tell you—he will be the fusion of all races, perhaps the coming superman.”
—Israel Zangwill (1864–1926)