TMPRSS2 Gene Fusion
ERG can fuse with TMPRSS2 protein to form an oncogenic fusion gene that is commonly found in human prostate cancer, especially in hormone-refractory prostate cancer. This suggests that ERG overexpression may contribute to development of androgen-independence in prostate cancer through disruption of androgen receptor signaling.
Read more about this topic: ERG (gene)
Famous quotes containing the word fusion:
“Sadism and masochism, in Freud’s final formulation, are fusions of Eros and the destructive instincts. Sadism represents a fusion of the erotic instincts and the destructive instincts directed outwards, in which the destructiveness has the character of aggressiveness. Masochism represents the fusion of the erotic instincts and the destructive instincts turned against oneself, the aim of the latter being self-destruction.”
—Patrick Mullahy (b. 1912)