Biological Effects
Generally, EETs cause:
- Calcium release from intracellular stores
- Increased sodium-hydrogen antiporter activity
- Increased cell proliferation
- Decreased cyclooxygenase activity
Other effects are specific to certain cells or locations:
- EETs are cardioprotective after ischemic heart attack and reperfusion.
- They act in the corpus cavernosum to maintain penile erection.
- Specific epoxidation of EET sites produces endogenous PPARĪ± agonists.
- Decreased release of somatostatin, insulin and glucagon from endocrine cells.
- Vasodilation and angiogenesis in blood vessels.
- Increased risk of tumor adhesion on endothelial cells
- Decreased platelet aggregation
Read more about this topic: Epoxyeicosatrienoic Acid
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