Epithelial Root Sheath - Evolution of HERS

Evolution of HERS

Hertwig's epithelial root sheath was not discovered in any mammalian species. Instead this epithelial structure was discovered by Oskar Hertwig in 1874 in an amphibian. While in mammalian the HERS is rather a transient structure in amphibians it is more or less a permanent one. Here the root epithelium does not fenestrate like in mammalians. Within vertebrates 3 distinct stages of HERS development can be observed.

Hertwigs sheath is derived from the internal and external enamel epithelium of the enamel organ. The sheath is also responsible for multiple roots (medial growth) and lateral canals (break in epithelium).

1. In teleosts and chondrichthyans no HERS or root is really formed, and tooth development is restricted to crown development. An inflexible joint is formed between the tooth and the bone at the apical end of the tooth where the epithelium remains open.
2. In amphibians and non-crocodilian reptiles a continuous root sheath or HERS is formed without fragmentation of the epithelium. Once again a rather rigid connection between bone and tooth is formed at the apical end of the tooth where no epithelium is present.
3. In crocodilians and mammals the HERS is a transient structure and fragments to form the epithelial cell rests of Malassez. Through the gaps in the root epithelium elements of the periodontal ligament can migrate and form a flexible connection between bone and root.