Intramolecular Ene Reactions
Intramolecular ene reactions benefit from less negative entropies of activation than their intrermolecular counterparts, so are usually more facile, occurring even in the case of simple enophiles, such as unactivated alkenes and alkynes. The high regio- and stereoselectivities that can be obtained in these reactions can offer considerable control in the synthesis of intricate ring systems.
Considering the position of attachment of the tether connecting the ene and enophile, Oppolzer has classified both thermal and Lewis acid-catalyzed intramolecular ene reactions as types I, II and III, and Snider has added a type IV reaction (Figure 7). In these reactions, the orbital overlap between the ene and enophile is largely controlled by the geometry of the approach of components.
Read more about this topic: Ene Reaction
Famous quotes containing the word reactions:
“In this Journal, my pen is a delicate needle point, tracing out a graph of temperament so as to show its daily fluctuations: grave and gay, up and down, lamentation and revelry, self-love and self-disgust. You get here all my thoughts and opinions, always irresponsible and often contradictory or mutually exclusive, all my moods and vapours, all the varying reactions to environment of this jelly which is I.”
—W.N.P. Barbellion (1889–1919)