Chiral Pool Synthesis
Chiral pool synthesis is the easiest approach: A chiral starting material is manipulated through successive reactions using achiral reagents that retain its chirality to obtain the desired target molecule. This is especially attractive for target molecules having the similar chirality to a relatively inexpensive naturally occurring building-block such as a sugar or amino acid. However, the number of possible reactions the molecule can undergo is restricted, and tortuous synthetic routes may be required. Also, this approach requires a stoichiometric amount of the enantiopure starting material, which may be rather expensive if not occurring in nature, whereas chiral catalysis requires only a catalytic amount of chiral material.
Read more about this topic: Enantioselective Synthesis
Famous quotes containing the words pool and/or synthesis:
“Just getting in the pool for seven straight hours is unbearable to me.... It’s grueling. There’s nothing physically pleasurable about it. If you’re doing a hard workout, you’re throwing up in the gutter. At night you cling to your pillow and just hope that your body revives before you have to go back and do it again.”
—Diana Nyad (b. 1949)
“It is in this impossibility of attaining to a synthesis of the inner life and the outward that the inferiority of the biographer to the novelist lies. The biographer quite clearly sees Peel, say, seated on his bench while his opponents overwhelm him with perhaps undeserved censure. He sees him motionless, miserable, his head bent on his breast. He asks himself: “What is he thinking?” and he knows nothing.”
—Andre Maurois (1885–1967)