El Supremo or il Supremo ("the supreme one" in Spanish and Italian respectively) may refer to:
- José Gaspar Rodríguez de Francia (1766-1840), Paraguayan dictator
- Pasquale Condello (born 1950), leader of the Italian 'Ndrangheta crime organization
- El Supremo (wrestler), ring name of Mexican professional wrestler Salvador Cuevas Ramírez (1942-2010)
- El Supremo, a fictional character in the Horatio Hornblower novel The Happy Return (1937)
- Vriesea 'El Supremo', a hybrid cultivar of the genus Vriesea