Edward Creighton (August 31, 1820 – November 5, 1874) was a prominent pioneer businessman in early Omaha, Nebraska. The brother of John A. Creighton, the Creightons were responsible for founding many institutions that were central to the growth and development of Omaha. Married to Mary Creighton in their native Dayton, Ohio, Edward relied on Mary to carry out his request to create a college, which eventually became Creighton University.