Ebersole may refer to:

  • Christine Ebersole (born 1953), American actress and singer
  • Frank Ebersole (1919-2009), American philosopher
  • John Ebersole (born 1948), American former National Football League player
  • Lucinda Ebersole, critic, editor and fiction writer
  • Mark C. Ebersole, American academic
  • P. David Ebersole (born 1964), American television director and filmmaker
  • Brian Ebersole (born 1980), American mixed martial artist