Dupuy de Lome may refer to:
- Enrique Dupuy de Lôme, Spanish Minister to the United States in 1892
- Henri Dupuy de Lôme, a French naval architect in the 19th century
- French armoured cruiser Dupuy de Lôme (1887), an armoured cruiser of the French navy which entered service in 1890, named after naval architect Henri Dupuy de Lôme
- Dupuy de Lôme (A759), an intelligence ship of the French Navy which entered service in 2006, also named after Henri Dupuy de Lôme