Duane may refer to:
- Duane, New York, a US town
- Duane Barry, 29th episode of The X-Files
- Duane Hopwood, a 2005 film featured in the Sundance Film Festival
- USCGC Duane (WPG-33), a US Coast Guard cutter and artificial-reef shipwreck
- Duane (surname), people with the surname Duane
- Duane (given name), people with the given name Duane