In biochemistry, a dual-specificity kinase (EC 2.7.12.1) is a kinase that can act as both tyrosine kinase and serine/threonine kinase.
MEKs, involved in MAP pathways, are principal examples of dual-specificity kinases. Other common examples include:
- ADK1
- Arabidopsis dual specificity kinase 1
- CLK1, CLK2, CLK3, CLK4
- DSTYK
- DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4
- Mps1p
- TESK1, TESK2
- TTK
The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating).