DRE may refer to:

  • Dre (album, 2010 album by American rapper Soulja Boy Tell 'Em
  • André 3000, also known as Dré
  • Andre Merritt, also known as Dre, songwriter and member of the Graffiti Artizts
  • Dr. Dre, American record producer and rapper
  • Mac Dre, deceased American rapper
  • Dre & Vidal
  • Davidson Road Elementary school, in Winfield, British Columbia, Canada
  • Defect Removal Efficiency, a metric used by Quality Control departments of businesses
  • Defence Research Establishment, former designation (ca. 1970 until 2000) of each of the Defence Research and Development Canada research centres
  • Digital Rectal Examination, in medicine
  • DRE voting machine
  • Director of Religious Exploration, a title in most congregations of the Unitarian Church
  • Disability & Rehabilitation, a medical journal
  • Division de la réglementation des explosifs (DRE, Explosives Regulatory Division in English), a division of Natural Resources Canada
  • Doctor of Religious Education
  • Drug Recognition Expert
  • Dry Rock Equivalent, used in volcanology