Kildare told the story of a young intern, Dr. James Kildare (Richard Chamberlain), working in a fictional large metropolitan hospital (Blair General) while trying to learn his profession, dealing with the problems of the patients, and winning the respect of the senior doctor, Dr. Leonard Gillespie (Raymond Massey).
In the series' first episode, Gillespie tells the earnest Kildare, "Our job is to keep people alive, not to tell them how to live." Kildare ignores the advice, which provides the basis for stories over the next four seasons, many with a soap opera touch. The series was largely responsible for making Chamberlain, who beat 35 other contenders for the role, a teen idol in the 1960s. He also recorded a song, "Three Stars Will Shine Tonight," with the music from the show's familiar opening theme. In 2006 Chamberlain reprised the role in a parody of Grey's Anatomy (along with other famous TV doctors from Julia, St. Elsewhere, M*A*S*H and The Love Boat) on the 2006 TV Land Awards.
A second television series, titled Young Dr. Kildare, premiered in first-run syndication in 1972. Starring Mark Jenkins as Dr. Kildare and Gary Merrill as Dr. Gillespie, it lasted for only one season of 24 episodes.