Downhill folding is a process in which a protein folds without encountering any significant macroscopic free energy barrier. It is a key prediction of the folding funnel hypothesis of the energy landscape theory of proteins.
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Famous quotes containing the words downhill and/or folding:
“To get through their days, nervous natures such as mine have various speeds as do automobiles. There are uphill and difficult day which take an eternity to climb, and downhill days which can be quickly descended.”
—Marcel Proust (18711922)
“Theres only one way for an individual to remain upright, not to fall to pieces, not to sink into the mire of self-oblivion ... or self-contempt. Thats calmly to turn away from everything, to say, Enough! and, folding ones useless arms across ones empty breast, to retain the ultimate, the sole attainable virtue, the virtue of recognizing ones own insignificance.”
—Ivan Sergeevich Turgenev (18181883)