Plot
In 2008, the Reaper virus infects Scotland and is being walled off by the British government. A Scottish woman begs soldiers retreating by helicopter to take her injured little girl with them, but the helicopter is already overloaded. One of the soldiers sacrifices his place for the girl, who is not infected.
The quarantine is deemed a success, with the remaining Scottish population and the virus apparently dying off. In the decades after, diplomatic relations between Great Britain and the rest of the world is destroyed because of genocidal quarantine, causing a depression and civil unrest. A police raid finds that the Reaper Virus has appeared in a London ghetto. British Prime Minister Hatcher and his right-hand-man Canaris share with domestic security chief Captain Nelson news of survivors in Scotland, and they believe a cure may exist. They order Nelson to send a team into Scotland to find medical researcher Dr. Kane, who was working on a cure when Scotland was quarantined. Nelson chooses Major Eden Sinclair, the little girl now grown up, to lead the team.
North of the wall, while searching for survivors, Sinclair and her team are ambushed by a gang of Marauders. After losing numerous members of their group, Sinclair and team mate Dr. Talbot are captured while team mates Sgt. Norton and Dr. Stirling manage to escape. Sinclair is interrogated and tortured by Sol, the leader of the Marauders. While Sol has Dr. Talbot barbecued alive, Sinclair escapes with a local prisoner, Cally, and kills Viper, Sol's lover.
Reuniting with Sgt. Norton and Dr. Stirling, they make their escape via a train driven by Joshua, Cally's friend. They are surrounded by Kane's medieval soldiers, Joshua is killed, and the rest are taken prisoner. Kane informs Sinclair that there is no cure, just people with natural immunity. Kane sentences the group to death, but Sinclair defeats Kane's executioner while the others escape from the prison. The remaining survivors retreat to an underground facility and find a Bentley in storage. Norton is killed by Kane's men, and Sinclair, Cally and Dr. Stirling escape in the Bentley to the quarantine wall.
After a long, high-speed road battle and escape from Sol's Marauders, Canaris arrives in a helicopter gunship. Sinclair secretly videos Canaris saying that he will use Cally's immunity to develop a cure – but only after letting more citizens on his side of the wall die off. Sinclair chooses to stay in her Scottish homeland, delivering Sol's head to the Maurauders and becoming their new leader. Nelson flies a helicopter into the quarantine zone to speak with her and she gives him a recording of the Canaris video, which is soon broadcast to the country.
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