Donohue is an originally an Irish surname which is abbreviated from O Donohue. (Irish: Ó Donnachú). It may refer to:
- Adam Donohue (born 1990), Australian rules footballer
- David Donohue (born 1967), American race car driver
- Erin Donohue (born 1983), American Track & Field athlete
- Harold Donohue (1901-1984), American politician
- Jack Donohue (basketball) (1931-2003), American basketball coach
- Jerry Donohue (1920-1985), American theoretical and physical chemist
- Jim Donohue (born 1938), American baseball player
- Keith Donohue (disambiguation)
- Larry Donohue (born 1955), former Australian rules footballer
- Mark Donohue (1937-1975), American racecar driver
- Mary Donohue (21st century), American judge of the New York Court of Claims
- Nigel Donohue (born 1969), British judoka
- Pat Donohue (born 1953), American fingerstyle guitarist
- Pete Donohue (1900-1988), American baseball player
- Peter M. Donohue (21st century), American Roman Catholic priest
- Peter M. Donohue (21st century), American Roman Catholic priest
- Tom Donohue (born 1952), retired professional baseball player
- Tom J. Donohue (21st century), American president and CEO of the United States Chamber of Commerce
- William A. Donohue (born 1947), American president of the Catholic League for Religious and Civil Rights in the United States