Scientific Career
Metcalf studied medicine at the University of Sydney, and had his first experience of medical research in the laboratory of Professor Patrick de Burgh. In 1954 Metcalf was awarded up a Carden Fellowship from the Anti-Cancer Council of Victoria at the Walter and Eliza Hall Institute of Medical Research. There he initially studied virology and leukemia, later transitioning to hematology.
Metcalf's pioneering research revealed the control of blood cell formation and the role of hematopoietic cytokines. In the 1960s he developed techniques to culture blood cells, which led to the discovery of colony-stimulating factors (CSFs), including macrophage colony-stimulating factor, granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor. CSFs are cytokines that control white blood cell formation and are responsible for resistance to infection. CSFs are now widely used to boost the immune system for patients receiving chemotherapy, and to mobilise blood stem cells for transplants.
Read more about this topic: Donald Metcalf
Famous quotes containing the words scientific and/or career:
“The scientific mind is atrophied, and suffers under inherited cerebral weakness, when it comes in contact with the eternal woman—Astarte, Isis, Demeter, Aphrodite, and the last and greatest deity of all, the Virgin.”
—Henry Brooks Adams (1838–1918)
“From a hasty glance through the various tests I figure it out that I would be classified in Group B, indicating “Low Average Ability,” reserved usually for those just learning to speak the English Language and preparing for a career of holding a spike while another man hits it.”
—Robert Benchley (1889–1945)