Cast
- Dan Aykroyd — Clifford Skridlow/Doctor Detroit
- Howard Hesseman — Smooth Walker
- Fran Drescher — Karen Blittstein
- Donna Dixon — Monica McNeil
- Lydia Lei — Jasmine Wu
- T. K. Carter — Diavolo Washington
- Lynn Whitfield — Thelma Cleland
- Kate Murtagh — Mom
- George Furth — Arthur Skridlow
- Nan Martin — Margaret Skridlow
- Peter Aykroyd — Mr. Frankman
- Glenne Headly — Miss Debbylike
- Robert Cornthwaite — Professor Blount
- Parley Baer — Judge Robert E. Lee Davis-Jackson
- John Kapelos — Rush Street Dude
- James Brown — Bandleader (himself)
- Steven Williams — Junior Sweet
- Andrew Duggan — Harmon Rausehorn
- Blackie Dammett - Eddie Four Eyes
Read more about this topic: Doctor Detroit
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