Defects in Mismatch Repair
Mutations in the human homologues of the Mut proteins affect genomic stability, which can result in microsatellite instability (MI). MI is implicated in most human cancers. Specifically the overwhelming majority of hereditary nonpolyposis colorectal cancers (HNPCC) are attributed to mutations in the genes encoding the MutS and MutL homologues MSH2 and MLH1 respectively, which allows them to be classified as tumour suppressor genes. A subtype of HNPCC is known as Muir-Torre Syndrome (MTS) which is associated with skin tumors.
Read more about this topic: DNA Mismatch Repair
Famous quotes containing the words defects in, defects and/or repair:
“We often make use of envenomed praise, that reveals on the rebound, as it were, defects in those praised which we dare not expose any other way.”
—François, Duc De La Rochefoucauld (1613–1680)
“A fool may be a dangerous customer, but the fact of his having such a vulnerable top-end turns danger into a first-rate sport; and whatever defects the old administration in Russia had, it must be conceded that it possessed one outstanding virtue—a lack of brains.”
—Vladimir Nabokov (1899–1977)
“Better to repair the pen after the sheep have escaped than not at all.”
—Chinese proverb.