Age-associated Accumulation of DNA Damage and Decline in Gene Expression
Further information: DNA damage (naturally occurring)In tissues composed of non- or infrequently replicating cells, DNA damages can accumulate with age and lead either to loss of cells, or, in surviving cells, loss of gene expression. Accumulated DNA damages are usually measured directly. Numerous studies of this type have indicated that oxidative damage to DNA is particularly important. The loss of expression of specific genes can be detected at both the mRNA level and protein level.
Read more about this topic: DNA Damage Theory Of Aging
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