Disappearance may refer to:
- Forced disappearance, when an organization forces a person to vanish from public view
- Unexplained disappearances, the disappearance of objects, animals or people without apparent reason or cause
- Disappearance (film), a 2002 U.S. TV movie
- Disappearance (novel), a novel by Jude Watson
- Disappearances (film), a 2006 film
- "Disappearance", an episode of the television series Dynasty
- A Series of Unfortunate Events No.3: The Wide Window or, Disappearance!, a special edition of the novel The Wide Window by Lemony Snicket