Diffuse nonepidermolytic palmoplantar keratoderma (also known as "Diffuse orthohyperkeratotic keratoderma," "Hereditary palmoplantar keratoderma," "Keratosis extremitatum progrediens," "Keratosis palmoplantaris diffusa circumscripta," "Tylosis," "Unna–Thost disease", and "Unna–Thost keratoderma") is inherited as an autosomal dominant condition and is present from infancy, characterized by a well-demarcated, symmetric, often "waxy" keratoderma involving the whole of the palms and soles.
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“An oblong puddle inset in the coarse asphalt; like a fancy footprint filled to the brim with quicksilver; like a spatulate hole through which you can see the nether sky. Surrounded, I note, by a diffuse tentacled black dampness where some dull dun dead leaves have stuck. Drowned, I should say, before the puddle had shrunk to its present size.”
—Vladimir Nabokov (1899–1977)