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Diamyd, a (GAD65 based, type 1 diabetes vaccine). Injections with GAD65, an autoantigen involved in type 1 diabetes, has in clinical trials delayed the destruction of beta cells for at least 30 months, without serious adverse effects. Patients treated with the substance showed higher levels of regulatory cytokines, thought to protect the beta cells. Phase III trials are under way in the USA and in Europe. Future applications can include latent autoimmune diabetes and prevention of type 1 diabetes. Two prevention studies will start in 2009.
NTDDS (Nerve Targeting Drug Delivery System) - A viral delivery system of proteins to nervous tissue (Nerve Targeted Drug Delivery System, NTDDS) that can be used e.g. against chronic pain. A phase I trial has shown positive results.
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