Comparison Between LADA, Type 1 Diabetes and Type 2 Diabetes
LADA is slow-onset Type 1 autoimmune diabetes in adulthood (NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases ).
- Onset: Type 1 diabetes onsets rapidly and at a younger age than does LADA.
- Family history: There is often a family history of autoimmune conditions (for example, rheumatoid arthritis, thyroid diseases, etc.). Furthermore, some individuals with LADA may have a family history of T2DM.
- Antibodies: Persons with type 1 diabetes and LADA usually test positive for certain (same) antibodies (GAD, ICA, IA-2) that are not present in type 2 diabetes. Moreover, there are also TCF7L2 genes associated with Type 2 diabetes involved in latent autoimmune diabetes of adults.
- GAD antibodies: Persons with LADA usually test positive for GAD antibodies, whereas in type 1 diabetes these antibodies are more commonly seen in adults rather than in children.
- Lifestyle and excess weight: People with LADA typically have a normal BMI or may be underweight due to weight loss prior to diagnosis. But some people with LADA may be overweight to mildly obese. LADA (Type 1 diabetes) is an autoimmune disease that cannot be prevented.
- Prognosis: About 80% of all persons initially diagnosed with type 2, who also have GAD antibodies, will become insulin dependent within 3 to 12 years (according to differing LADA sources). Those with both GAD and IA2 antibodies, however, will become insulin dependent sooner. LADA occurs slowly, but progresses towards insulin dependency.
- Treatment: Although LADA may appear to initially respond to similar treatment (lifestyle and medications, sometimes weight loss if needed) as type 2 diabetes, it will not halt or slow the progression of beta cell destruction, and people with LADA will eventually become insulin dependent.
Read more about this topic: Diabetes Type 1.5
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