Determination may refer to:
- Cell fate determination
- Co-determination
- Coefficient of determination
- Determination (God Forbid album), 2001
- Determination (Tommy Emmanuel album), 1992
- Expert determination
- Hidden surface determination
- Orbit determination
- Presidential Determination
- Sex-determination
- Self-determination
- Van Slyke determination
- Zeisel determination
- Zerewitinoff determination
- Determination, a concept in dialectics