The name Destouches may refer to:
- André Cardinal Destouches, French composer of Les élémens
- Franz Seraph von Destouches, German composer
- Louis-Camus Destouches, artillery officer and father of Jean le Rond d'Alembert
- Louis-Ferdinand Destouches, better known as Louis-Ferdinand Céline
- Philippe Néricault Destouches, French dramatist