Deleted in Colorectal Cancer

Deleted In Colorectal Cancer

Identifiers Symbols DCC; CRC18; CRCR1; IGDCC1 External IDs OMIM: 120470 MGI: 94869 HomoloGene: 21081 GeneCards: DCC Gene

Gene Ontology
Molecular function transcription coactivator activity
transmembrane signaling receptor activity
netrin receptor activity
protein binding
identical protein binding
Cellular component cytosol
plasma membrane
integral to membrane
growth cone membrane
membrane raft
Biological process neuron migration
response to amphetamine
apoptotic process
induction of apoptosis
axon guidance
positive regulation of neuron projection development
negative regulation of neuron projection development
spinal cord ventral commissure morphogenesis
dorsal/ventral axon guidance
regulation of apoptotic process
negative regulation of collateral sprouting
positive regulation of ERK1 and ERK2 cascade
negative regulation of dendrite development
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1630 13176 Ensembl ENSG00000187323 ENSMUSG00000060534 UniProt P43146 P70211 RefSeq (mRNA) NM_005215.3 NM_007831.3 RefSeq (protein) NP_005206.2 NP_031857.2 Location (UCSC) Chr 18:
49.87 – 51.06 Mb Chr 18:
71.26 – 72.35 Mb PubMed search

Deleted in Colorectal Carcinoma, also known as DCC, is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer. While the official, full name of this gene is Deleted in Colorectal Carcinoma, it is almost universally called Deleted in Colorectal Cancer. The protein product of DCC is a single transmembrane receptor also known as DCC, and it has the same interchangeable name.

Since it was first discovered in a colorectal cancer study in 1990, DCC has been the focus of a significant amount of research. DCC held a controversial place as a tumour suppressor gene for many years, and is well known as an axon guidance receptor that responds to netrin-1.

More recently DCC has been characterized as a dependence receptor, and theories have been put forward that have revived interest in DCC's candidacy as a tumour suppressor gene, as it may be a ligand-dependent suppressor that is frequently epigenetically silenced.

Read more about Deleted In Colorectal Cancer:  Background, Structure, DCC As A Dependence Receptor, Developmental and Neurological Roles, Role in Cancer, Pharmacology, Interactions, History of Research

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