Deleted In Colorectal Cancer
| Gene Ontology | |
|---|---|
| Molecular function | • transcription coactivator activity • transmembrane signaling receptor activity • netrin receptor activity • protein binding • identical protein binding |
| Cellular component | • cytosol • plasma membrane • integral to membrane • axon • growth cone membrane • membrane raft |
| Biological process | • neuron migration • response to amphetamine • apoptotic process • induction of apoptosis • axonogenesis • axon guidance • positive regulation of neuron projection development • negative regulation of neuron projection development • spinal cord ventral commissure morphogenesis • dorsal/ventral axon guidance • regulation of apoptotic process • negative regulation of collateral sprouting • positive regulation of ERK1 and ERK2 cascade • negative regulation of dendrite development |
| Sources: Amigo / QuickGO | |
49.87 – 51.06 Mb
71.26 – 72.35 Mb
Deleted in Colorectal Carcinoma, also known as DCC, is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer. While the official, full name of this gene is Deleted in Colorectal Carcinoma, it is almost universally called Deleted in Colorectal Cancer. The protein product of DCC is a single transmembrane receptor also known as DCC, and it has the same interchangeable name.
Since it was first discovered in a colorectal cancer study in 1990, DCC has been the focus of a significant amount of research. DCC held a controversial place as a tumour suppressor gene for many years, and is well known as an axon guidance receptor that responds to netrin-1.
More recently DCC has been characterized as a dependence receptor, and theories have been put forward that have revived interest in DCC's candidacy as a tumour suppressor gene, as it may be a ligand-dependent suppressor that is frequently epigenetically silenced.
Read more about Deleted In Colorectal Cancer: Background, Structure, DCC As A Dependence Receptor, Developmental and Neurological Roles, Role in Cancer, Pharmacology, Interactions, History of Research
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