December 28, 1981 (Monday)
- Elizabeth Jordan Carr became the first American "test-tube baby", and 25th in history, at her birth at 7:46 pm in Norfolk, Virginia. She had been conceived by in vitro fertilization in the laboratory at Bourn in England; coincidentally, Elizabeth's birth weight was 2.61 kilograms, precisely the weight of the first test-tube baby, Louise Brown, in 1978
- Born: Sienna Miller, American-born British film actress, in New York; and Khalid Boulahrouz, Dutch footballer, in Maassluis
- Died: Allan Dwan, 96, Canadian-born film director
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