Decay-accelerating Factor
| Gene Ontology | |
|---|---|
| Molecular function | • receptor activity |
| Cellular component | • extracellular region • plasma membrane • integral to plasma membrane • cell surface • anchored to membrane • membrane raft |
| Biological process | • complement activation, classical pathway • elevation of cytosolic calcium ion concentration • regulation of complement activation • innate immune response • respiratory burst |
| Sources: Amigo / QuickGO | |
207.49 – 207.53 Mb
132.27 – 132.29 Mb
Complement decay-accelerating factor also known as CD55 is a protein that, in humans, is encoded by the CD55 gene.
Decay accelerating factor is a 70 kDa membrane protein that regulates the complement system on the cell surface. It prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.
This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.
Read more about Decay-accelerating Factor: Pathology
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