People
- Francesco de Sanctis (architect), Italian architect
- Francesco de Sanctis (critic) (1817 – 1883), Italian literary critic
- Gaetano De Sanctis (1870 – 1957), Italian historian and lifetime senator (1950-1957)
- Giovanni de Sanctis, Italian astronomer at the Osservatorio Astronomico di Torino (Astronomical Observatory of Turin) in Turin, Italy
- Guglielmo de Sanctis (1829–1911), Italian painter
- St Michael de Sanctis (1591 - 1625), Discalced Trinitarian priest from Vic, Catalonia
Roman DeSanctis, Cardiologist at Massachusetts General Hospital and Distinguished Professor, Harvard Medical School
- Morgan De Sanctis (born 1977), Italian football goalkeeper
- Sante De Sanctis (1862 - 1935), Italian doctor, psychologist and psychiatrist
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