de Michelis (or alternate spellings Demichelis, Demicheli) may refer to:
- Cesare G. De Michelis, professor of Russian literature at the University of Rome
- Gianni De Michelis, Italian politician
- Martín Demichelis, Argentine footballer
- Alberto Demicheli, Uruguayan politician
- Tulio Demicheli, Argentine film director
- Sofía Álvarez Vignoli de Demicheli, First Lady of Uruguay