de Ayala may refer to:
- Adelardo López de Ayala y Herrera (1828–1879), Spanish writer and politician
- Jaime Zobel de Ayala (born 1934), prominent Filipino businessman and photographer
- Juan de Ayala (1745–1797), Spanish naval officer
- Pero López de Ayala (1332–1407), Castilian statesman, historian, poet, chronicler, chancellor, and courtier
- Pedro de Ayala (d. January 1513), Spanish diplomat
- Pilar López de Ayala (born 1978), Spanish film actress
- Ramón Pérez de Ayala (circa 1880–1962), Spanish writer