Assembly
Site of assembly is believed to occur near TOM/TIM, where complex intermediates are accessible to bind with subunits imported from cytosol. Hemes and cofactors are inserted into subunits I & II Subunits I and IV initiate assembly. Other subunits may form sub-complex intermediates that later bind to others to form COX complex. In post-assembly modifications, the enzyme is dimerized, which is required for active/efficient enzyme action. Dimers are connected by a cardiolipin molecule.
Read more about this topic: Cytochrome C Oxidase
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“A man may be a heretic in the truth; and if he believe things only because his pastor says so, or the assembly so determines, without knowing other reason, though his belief be true, yet the very truth he holds becomes his heresy.”
—John Milton (1608–1674)
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—Mrs. H. O. Ward (1824–1899)
“Had every Athenian citizen been a Socrates, every Athenian assembly would still have been a mob.”
—James Madison (1751–1836)