Cyclin K

Cyclin K

Identifiers Symbols CCNK; CPR4 External IDs OMIM: 603544 HomoloGene: 14748 GeneCards: CCNK Gene

Gene Ontology
Molecular function	• cyclin-dependent protein kinase activity • protein binding • RNA polymerase II carboxy-terminal domain kinase activity • protein kinase binding
Cellular component	• cyclin K-CDK12 complex • cyclin K-CDK13 complex
Biological process	• regulation of cyclin-dependent protein kinase activity • regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter • response to DNA damage stimulus • mitosis • cell division • negative regulation of cell cycle arrest
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8812 12454 Ensembl ENSG00000090061 ENSMUSG00000021258 UniProt O75909 O88874 RefSeq (mRNA) NM_001099402 NM_009832 RefSeq (protein) NP_001092872 NP_033962 Location (UCSC) Chr 14:
99.95 – 100 Mb Chr 12:
108.18 – 108.2 Mb PubMed search

Cyclin-K is a protein that in humans is encoded by the CCNK gene.

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.