The Binding Event
The ligand might be placed at the bottom of the cavity due to interactions with the phosphate binding cassette (PBC). This cavity refers to a region in the CNBD formed by the β roll, a two-looped β helix. Changes induced by ligand binding occur in α helices (αA, αB, and αC and PBC helix). The β roll only undergoes small changes during binding. After the ligand is seated, αB and αC helices arrange themselves so that they form a cap over the cavity. How binding affects the αA helix is still unclear.
Read more about this topic: Cyclic Nucleotide-gated Ion Channel
Famous quotes containing the words binding and/or event:
“Hate traps us by binding us too tightly to our adversary.”
—Milan Kundera (b. 1929)
“An event has happened, upon which it is difficult to speak, and impossible to be silent.”
—Edmund Burke (1729–1797)