Clinical Significance
Upregulated CTP synthase activity has been widely seen in human and rodent tumors.
Mutations in the CTP synthase have been seen to confer resistance to cytotoxic drugs such as cytosine arabinoside (ara-C) in a Chinese hamster ovary (CHO) cell model of leukemia though such mutations were not found in human patients with ara-C resistance.
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“History is the interpretation of the significance that the past has for us.”
—Johan Huizinga (1872–1945)