Crespo may refer to:
- Hernán Crespo, Argentine footballer
- Jimmy Crespo, former Aerosmith and Rod Stewart lead guitarist
- Jorge J. Crespo de la Serna (1887–1978), Mexican artist, art critic and art historian
- José Ángel Crespo, Spanish footballer
- Elvis Crespo, Puerto Rican singer
- Eduardo Alonso-Crespo, an Argentinian composer of classical music
- Remigio Crespo Toral, Ecuadorian writer
- Villa Crespo, neighbourhood in Buenos Aires, Argentina
- Joseph Crespo, French rugby league footballer
- Nexus S, Android phone with the codename Crespo
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