Clinical Significance
Inhibition of this enzyme, for example by a compound in liquorice, results in a condition known as pseudohyperaldosteronism. A genetically inherited deficiency of HSD11B2 is the underlying cause of the syndrome of apparent mineralocorticoid excess.
Read more about this topic: Corticosteroid 11-beta-dehydrogenase Isozyme 2
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“History is the interpretation of the significance that the past has for us.”
—Johan Huizinga (1872–1945)