A contiguous gene syndrome is a syndrome caused by abnormalities of 2 or more genes that are located next to each other on a chromosome. Prader-Willi Syndrome, which is caused by the microdeletion of 15q11-13, is a common example. Prader-Willi syndrome occurs when the deletion occurs on the paternal chromosome. If this deletion occurs on the maternal chromosome, it causes the Angelman syndrome. DiGeorge syndrome(deletion of 22q11.2) is a particularly well known example. WAGR syndrome (deletions of 11p13) is another example.
Famous quotes containing the words contiguous and/or syndrome:
“A CAUSE is an object precedent and contiguous to another, and so united with it that the idea of the one determines the mind to form the idea of the other, and the impression of the one to form a more lively idea of the other.”
—David Hume (1711–1776)
“Women are taught that their main goal in life is to serve others—first men, and later, children. This prescription leads to enormous problems, for it is supposed to be carried out as if women did not have needs of their own, as if one could serve others without simultaneously attending to one’s own interests and desires. Carried to its “perfection,” it produces the martyr syndrome or the smothering wife and mother.”
—Jean Baker Miller (20th century)