A contiguous gene syndrome is a syndrome caused by abnormalities of 2 or more genes that are located next to each other on a chromosome. Prader-Willi Syndrome, which is caused by the microdeletion of 15q11-13, is a common example. Prader-Willi syndrome occurs when the deletion occurs on the paternal chromosome. If this deletion occurs on the maternal chromosome, it causes the Angelman syndrome. DiGeorge syndrome(deletion of 22q11.2) is a particularly well known example. WAGR syndrome (deletions of 11p13) is another example.
Famous quotes containing the words contiguous and/or syndrome:
“Now in contiguous drops the flood comes down,
Threat’ning with deluge this devoted town.
To shops in crowds the daggled females fly,
Pretend to cheapen goods, but nothing buy.”
—Jonathan Swift (1667–1745)
“Women are taught that their main goal in life is to serve others—first men, and later, children. This prescription leads to enormous problems, for it is supposed to be carried out as if women did not have needs of their own, as if one could serve others without simultaneously attending to one’s own interests and desires. Carried to its “perfection,” it produces the martyr syndrome or the smothering wife and mother.”
—Jean Baker Miller (20th century)