1q32 Region
In humans, the CR1 gene is located at on the long arm of chromosome 1 at band 32 (1q32) and lies within a complex of immunoregulatory genes. In 5’-3’ order the genes in this region are: membrane cofactor protein - CR1- complement receptor type 2 - decay-accelerating factor - C4-binding protein.
- Membrane cofactor protein is a widely distributed C3b/C4b binding regulatory glycoprotein of the complement system;
- decay-accelerating factor (DAF: CD55: Cromer antigen) protects host cells from complement-mediated damage by regulating the activation of C3 convertases on host cell surfaces;
- complement receptor 2 is the C3d receptor.
Factor H, another immunoregulatory protein, also maps to this location.
Read more about this topic: Complement Receptor 1
Famous quotes containing the word region:
“Biography is a very definite region bounded on the north by history, on the south by fiction, on the east by obituary, and on the west by tedium.”
—Philip Guedalla (1889–1944)
Related Phrases
Related Words