Complement Receptor 1 - 1q32 Region

1q32 Region

In humans, the CR1 gene is located at on the long arm of chromosome 1 at band 32 (1q32) and lies within a complex of immunoregulatory genes. In 5’-3’ order the genes in this region are: membrane cofactor protein - CR1- complement receptor type 2 - decay-accelerating factor - C4-binding protein.

• Membrane cofactor protein is a widely distributed C3b/C4b binding regulatory glycoprotein of the complement system;
• decay-accelerating factor (DAF: CD55: Cromer antigen) protects host cells from complement-mediated damage by regulating the activation of C3 convertases on host cell surfaces;
• complement receptor 2 is the C3d receptor.

Factor H, another immunoregulatory protein, also maps to this location.