Clopton may refer to:
People:
- David Clopton (1820–1892), Alabama politician
- Hugh Clopton (c. 1440 – 1496), Lord Mayor of the City of London
- John Clopton (1756–1816), a United States Representative
- Walter Clopton (died 1400), English lawyer and Chief Justice of the King's Bench
- Clopton Havers (1657–1702) pioneering English physician
- Clopton Lloyd-Jones (1858–1918), English businessman, footballer and cricketer
Places:
- Clopton, Cambridgeshire, a deserted medieval village
- Clopton, Northamptonshire, a small village and civil parish
- Clopton, Suffolk, a village
- Clopton, Alabama
- Clopton, Virginia (disambiguation), multiple locations
- Clopton Bridge, Stratford-upon-Avon, England
- Clopton House, near Stratford-upon-Avon, once owned by Hugh Clopton
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