Clonal Selection - Four Predictions of The Clonal Selection Hypothesis

Four Predictions of The Clonal Selection Hypothesis

  • Each lymphocyte bears a single type of receptor with a unique specificity (by V(D)J recombination).
  • Receptor occupation is required for cell activation.
  • The differentiated effector cells derived from an activated lymphocyte will bear receptors of identical specificity as the parental cell.
  • Those lymphocytes bearing receptors for self molecules will be deleted at an early stage.

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