Four Predictions of The Clonal Selection Hypothesis
- Each lymphocyte bears a single type of receptor with a unique specificity (by V(D)J recombination).
- Receptor occupation is required for cell activation.
- The differentiated effector cells derived from an activated lymphocyte will bear receptors of identical specificity as the parental cell.
- Those lymphocytes bearing receptors for self molecules will be deleted at an early stage.
Read more about this topic: Clonal Selection
Famous quotes containing the words predictions, selection and/or hypothesis:
“The Brahmins say that in their books there are many predictions of times in which it will rain. But press those books as strongly as you can, you can not get out of them a drop of water. So you can not get out of all the books that contain the best precepts the smallest good deed.”
—Leo Tolstoy (1828–1910)
“It is the highest and most legitimate pride of an Englishman to have the letters M.P. written after his name. No selection from the alphabet, no doctorship, no fellowship, be it of ever so learned or royal a society, no knightship,—not though it be of the Garter,—confers so fair an honour.”
—Anthony Trollope (1815–1882)
“The hypothesis I wish to advance is that ... the language of morality is in ... grave disorder.... What we possess, if this is true, are the fragments of a conceptual scheme, parts of which now lack those contexts from which their significance derived. We possess indeed simulacra of morality, we continue to use many of the key expressions. But we have—very largely if not entirely—lost our comprehension, both theoretical and practical, of morality.”
—Alasdair Chalmers MacIntyre (b. 1929)