CLK3 (gene)

Identifiers Symbols CLK3; PHCLK3; PHCLK3/152 External IDs OMIM: 602990 MGI: 1098670 HomoloGene: 101534 ChEMBL: 4226 GeneCards: CLK3 Gene EC number 2.7.12.1

Gene Ontology
Molecular function	• protein serine/threonine kinase activity • protein serine/threonine/tyrosine kinase activity • protein tyrosine kinase activity • ATP binding
Cellular component	• acrosomal vesicle • nucleus • nucleolus • nuclear speck • intermediate filament cytoskeleton
Biological process	• protein phosphorylation • peptidyl-tyrosine phosphorylation • regulation of RNA splicing • protein autophosphorylation
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 1198 102414 Ensembl ENSG00000179335 ENSMUSG00000032316 UniProt P49761 O35492 RefSeq (mRNA) NM_001130028 NM_007713 RefSeq (protein) NP_001123500 NP_031739 Location (UCSC) Chr 15:
74.89 – 74.93 Mb Chr 9:
57.75 – 57.77 Mb PubMed search

Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene.

The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform (phclk3 and pclk3/152) result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.